Latest Articles on Coronaviruses
- Dual ionization sources high-field asymmetric waveform ion mobility spectrometry with combined ultraviolet lamp source and corona discharge source Mon, 25 Sep 2023 06:00:00 -0400
Dual ionization sources combining an ultraviolet (UV) lamp source and a corona discharge (CD) source were first used as ionization sources for high-field asymmetric waveform ion mobility spectrometry (FAIMS) to switch ionization modes without changing hardware. The CD source was manufactured using a tungsten needle and a copper ring and its usability was verified. The UV source and the CD source were combined into the FAIMS sensor and multiple ionization modes were attempted by controlling their... - Clinical performance of sealants under different humidity control conditions: a split-mouth 1-year randomized trial Mon, 25 Sep 2023 06:00:00 -0400
CONCLUSION: It may be concluded that sealants effectively prevented caries, even when they were partially or totally lost, regardless of the material. The rubber dam isolation with a rubber dam promoted lower surface roughness and improved the retention rates. International Clinical Trials Registry Platform: #1111-1215-2832 (07/26/2018). - De novo missense variants in ZBTB47 are associated with developmental delays, hypotonia, seizures, gait abnormalities, and variable movement abnormalities Mon, 25 Sep 2023 06:00:00 -0400
The collection of known genetic etiologies of neurodevelopmental disorders continues to increase, including several syndromes associated with defects in zinc finger protein transcription factors (ZNFs) that vary in clinical severity from mild learning disabilities and developmental delay to refractory seizures and severe autism spectrum disorder. Here we describe a new neurodevelopmental disorder associated with variants in ZBTB47 (also known as ZNF651), which encodes zinc finger and BTB... - Functionalization strategies of metal-organic frameworks for biomedical applications and treatment of emerging pollutants: A review Sun, 24 Sep 2023 06:00:00 -0400
One of the representative coordination polymers, metal-organic frameworks (MOFs) material, is of hotspot interest in the multi field thanks to their unique structural characteristics and properties. As a novel hierarchical structural class, MOFs show diverse topologies, intrinsic behaviors, flexibility, etc. However, bare MOFs have less desirable biofunction, high humid sensitivity and instability in water, restraining their efficiencies in biomedical and environmental applications. Thus, a... - Kartogenin-loaded liposomes coated with alkylated chondroitin sulfate for cartilage repair Sun, 24 Sep 2023 06:00:00 -0400
Cartilage loss is a common clinical problem, which leads to significant pain, dysfunction, and even disability. As a result, there is growing interest in using small, non-protein molecules to protect or repair cartilage. Kartogenin (KGN), a small hydrophobic molecule, shows chondroprotective and chondrogenic properties. In this study, we embedded KGN in liposomes, and the whole system was stabilized by covering it with n-octadecylated (at two different substitution degrees) chondroitin sulfate... - Computational analysis of substrate recognition of Sars-Cov-2 Mpro main protease Sun, 24 Sep 2023 06:00:00 -0400
M^(pro) main protease takes an essential role in the Sars-Cov-2 viral life cycle by releasing the individual protein from the single poly-peptide chain via proteolytic cleavage in the beginning of the viral infection. Interfering with this step by inhibiting the protease with small compound-based inhibitors has been proven to be an effective strategy to treat the infection. Thus, understanding the substrate recognition mechanism of the M^(pro) main protease has gained great interest from the... - Enhancing the optical properties of [P(MMA-co-AN)/ZrO2]TF by doping fluorescein dye, TD-DFT/DMOl3 simulations and COVID-19 main protease docking Sat, 23 Sep 2023 06:00:00 -0400
Poly methyl methacrylate-co-acrylonitrile [P(MMA-co-AN)]^(HB) hybrid blend was first synthesized by precipitation polymerization and characterized by static light scattering. With a thickness of 200 ± 5 nm, the hybrid nanocomposite of [P(MMA-co-AN)/ZrO(2)]^(HNC) thin films were fabricated by spin coating method. X-Ray diffraction studies showed a monoclinic cell structure with an average crystalline size of 180 nm for the fabricated films. An improvement in the optical properties were figured... - Author Correction: The high-throughput atomization of polymer solutions for fiber synthesis in a single step aided with corona ionizers Fri, 22 Sep 2023 06:00:00 -0400
No abstract - The CORONA-VTE network registry: Revisiting the realities while encouraging enthusiasm Fri, 22 Sep 2023 06:00:00 -0400
No abstract - Mesenchymal stem cell implantation provides short-term clinical improvement and satisfactory cartilage restoration in patients with knee osteoarthritis but the evidence is limited: a systematic review performed by the early-osteoarthritis group of ESSKA-European knee associates section Fri, 22 Sep 2023 06:00:00 -0400
CONCLUSION: According to the available literature, MSCs implantation in patients with mild to moderate knee osteoarthritis is safe and provides short-term clinical improvement and satisfactory cartilage restoration, either as a standalone procedure or combined with HTO in cases with axial deformity. However, the evidence is limited due to the high heterogeneity among studies and the insufficient number of studies including a control group and mid-term outcomes.